{"id":4988,"date":"2025-06-18T09:52:39","date_gmt":"2025-06-18T06:52:39","guid":{"rendered":"https:\/\/www.ita-suomenbiopankki.fi\/?post_type=tutkimus&p=4988"},"modified":"2025-06-27T10:36:23","modified_gmt":"2025-06-27T07:36:23","slug":"molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr","status":"publish","type":"tutkimus","link":"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/","title":{"rendered":"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR)"},"content":{"rendered":"

Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) Lynch syndrome (LS) is common hereditary syndrome with an increased risk of colorectal, endometrial, and a dozen of other LS-related cancers, and caused by inherited defects in mismatch repair genes. Utilizing data from the Lynch Syndrome Research Registry, we have identified 800 LS associated tumors from 15 organs, to be obtained through Finnish Biobank requests. Our research aims to determine the mismatch repair deficiency and analyze the immune profiles of these tumors to identify the prevalent frameshift mutations allowing development of LS-specific ctDNA screening tests and validation of the vaccine developed for cancer prevention in LS.<\/p>\n","protected":false},"menu_order":0,"template":"","class_list":["post-4988","tutkimus","type-tutkimus","status-publish","hentry"],"acf":[],"yoast_head":"\nMolecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) - It\u00e4-Suomen biopankki<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) - It\u00e4-Suomen biopankki\" \/>\n<meta property=\"og:description\" content=\"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) Lynch syndrome (LS) is common hereditary syndrome with an increased risk of...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/\" \/>\n<meta property=\"og:site_name\" content=\"It\u00e4-Suomen biopankki\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-27T07:36:23+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Arvioitu lukuaika\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuutti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs2.uef.fi\\\/itasuomenbiopankki-vanha\\\/tutkimus\\\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\\\/\",\"url\":\"https:\\\/\\\/blogs2.uef.fi\\\/itasuomenbiopankki-vanha\\\/tutkimus\\\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\\\/\",\"name\":\"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) - 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It\u00e4-Suomen biopankki","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/","og_locale":"fi_FI","og_type":"article","og_title":"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) - It\u00e4-Suomen biopankki","og_description":"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) Lynch syndrome (LS) is common hereditary syndrome with an increased risk of...","og_url":"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/","og_site_name":"It\u00e4-Suomen biopankki","article_modified_time":"2025-06-27T07:36:23+00:00","twitter_card":"summary_large_image","twitter_misc":{"Arvioitu lukuaika":"1 minuutti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/","url":"https:\/\/blogs2.uef.fi\/itasuomenbiopankki-vanha\/tutkimus\/molecular-landscape-of-lynch-syndrome-associated-tumor-spectrum-finmmr\/","name":"Molecular landscape of Lynch syndrome-associated tumor spectrum (FinMMR) - 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